Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/1140
Título: Association of polymorphism of the ß(1, 4)-galactosyltransferase-I gene with milk production traits in Holsteins
Autor: Shahbazkia, Homayon Reza
Aminlari, Mahmoud
Cravador, A.
Palavras-chave: Galactosyltransferase
Lactose synthase
Milk production traits
Cattle
SNP
Marker assisted selection
Data: 2012
Citação: Shahbazkia, Homayon Reza; Aminlari, Mahmoud; Cravador, Alfredo. Association of polymorphism of the ß(1, 4)-galactosyltransferase-I gene with milk production traits in Holsteins. Molecular Biology Reports, 39, 6, 6715-6721, 2012.
Resumo: The b(1,4)-galactosyltransferase-I gene (b4galt1) encodes the catalytic part of the enzyme lactose synthase, responsible of lactose synthesis in the mammary gland. The complete coding region of the gene was screened for the presence of allelic variation among a sample of 1,200 Iranian Holstein cows, using PCR-SSCP technique followed by sequencing. Nine polymorphic nucleotide sites were identified- one in exons I and VI, two in exons II and III, and three in exon V. Altogether 18 different genotypes were assigned. Statistical analysis showed that the genotypes of B4GALT1 significantly affect milk, lactose, protein and total solid productions in both the first and second lactation (P\0.001). Variance component analysis considering restricted maximum likelihood showed that the major factor making differences in milk, lactose, protein and total solid productions among the studied cow is the b4galt1 genotype. We concluded that the b4galt1 gene is potentially associated with milk production traits in dairy cows and should be considered for further studies on genetics of the milk production traits.
Peer review: yes
URI: http://hdl.handle.net/10400.1/1140
ISSN: 0301-4851
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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