Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/2100
Título: Biocompatibility of chitosan carriers with application in drug delivery
Autor: Rodrigues, Susana
Dionísio, Marita
Remuñán-López, Carmen
Grenha, Ana
Palavras-chave: Biocompatibility
Chitosan
Cytotoxicity
Genotoxicity
Microparticles
Nanoparticles
Data: 2012
Resumo: Chitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a great capacity to produce drug delivery systems, ensuring the biocompatibility of the drug delivery vehicles is a highly relevant issue. Nevertheless, this subject is not addressed as frequently as desired and even though the application of chitosan carriers has been widely explored, the demonstration of systems biocompatibility is still in its infancy. In this review, addressing the biocompatibility of chitosan carriers with application in drug delivery is discussed and the methods used in vitro and in vivo, exploring the effect of different variables, are described. We further provide a discussion on the pros and cons of used methodologies, as well as on the difficulties arising from the absence of standardization of procedures.
Peer review: yes
URI: http://hdl.handle.net/10400.1/2100
ISSN: 2079-4983
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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