Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/2101
Título: Natural carriers for application in tuberculosis treatment
Autor: Costa, Hugo
Grenha, Ana
Palavras-chave: Controlled release
Drug delivery
Microparticles
Nanoparticles
Microencapsulation
Data: 2012
Citação: doi:10.3109/02652048.2012.726283
Resumo: Tuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects. Overcoming this problem demands the introduction of drug carriers releasing the antimicrobial agents in a targeted and sustained manner, allowing reduction in frequency and dosing numbers. Nano and microparticles have taken the forefront of this approach, providing the means for the desired improvement of therapeutic schedules. Natural polymers are strong candidates as matrix forming materials, usually exhibiting biocompatibility, biodegradability, low cost and some technological advantages as compared with synthetic counterparts. In this review, natural particulate carriers developed for tuberculosis therapy are presented, mainly focusing on the use of polysaccharides and lipids. Their effectiveness is discussed taking into account their composition. Finally, considerations on the general potential of natural materials for this application, as well as key factors still to be addressed, are discussed.
Peer review: yes
URI: http://hdl.handle.net/10400.1/2101
ISSN: 0265-2048
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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