Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3026
Título: Phenotypics study of mutant embryos for the gene ADTK1 in mice
Autor: Cunha, Nídia Sofia Maltez
Orientador: Belo, José António
Palavras-chave: Desenvolvimento embrionário
Formação óssea
Tubo Neural
Bone formation
Embryonic development
Data de Defesa: 2011
Resumo: A differential screening conducted to identify novel genes expressed in the anterior visceral endoderm (AVE) led to the isolation/identification of Adtk1, a gene coding for a protein with tyrosine and serine/threonine kinase domains. The analysis at birth of generated Adtk1 mouse mutants has been reported by our and other laboratories. Several defects were identified, namely the mutants were slightly smaller and had limbs with shortened long bones than wild-type littermates. In the course of this thesis it was observed that inbreeding Adtk1 mutation into the C57Bl6 background resulted in embryonic death identified by genotyped conceptus, suggesting the importance of this gene along the embryonic development. A more in-depth analysis of this mutation in mixed background (C57Bl6/DBA) revealed that Adtk1-/- animals also presented kidney defects. Furthermore, preliminary analysis of E9.5 Adtk1 KO embryos in a pure inbred background (C57Bl6) revealed that they display severe defects associated with neural tube closure.
Descrição: Dissertação de mest., Ciências Biomédicas (Biologia do Desenvolvimento Embrionário), Departamento de Ciências Biomédicas e Medicina, Univ. do Algarve, 2011
Peer review: yes
URI: http://hdl.handle.net/10400.1/3026
Designação: Mestrado em Ciências Biomédicas. Biologia do Desenvolvimento Embrionário
Aparece nas colecções:UA01-Teses

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