Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3551
Título: The ves hypothesis and protein misfolding
Autor: Cruzeiro, Leonor
Palavras-chave: Davydov/Scott model
Neurodegenerative diseases,
Ice worm
Data: 2011
Editora: American Institute of Mathematical Sciences
Citação: Cruzeiro, L.The ves hypothesis and protein misfolding, Discrete and Continuous Dynamical Systems - Series S, 4, 5, 1033-10, 2011.
Resumo: Proteins function by changing conformation. These conformational changes, which involve the concerted motion of a large number of atoms are classical events but, in many cases, the triggers are quantum mechani- cal events such as chemical reactions. Here the initial quantum states after the chemical reaction are assumed to be vibrational excited states, something that has been designated as the VES hypothesis. While the dynamics under classical force fields fail to explain the relatively lower structural stability of the proteins associated with misfolding diseases, the application of the VES hy- pothesis to two cases can provide a new explanation for this phenomenon. This explanation relies on the transfer of vibrational energy from water molecules to proteins, a process whose viability is also examined.
Peer review: yes
URI: http://hdl.handle.net/10400.1/3551
DOI: http://dx.doi.org/10.3934/dcdss.2011.4.1033
ISSN: 1937-1632
Versão do Editor: http://www.aimsciences.org/journals/displayArticles.jsp?paperID=5760
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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