Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3850
Título: Novel bioactive parathyroid hormone and related peptides in teleost fish
Autor: Canario, Adelino V. M.
Rotllant, J.
Fuentes, J.
Guerreiro, P. M.
Teodósio, H. R.
Power, Deborah
Clark, M. S.
Palavras-chave: Parathyroid hormone
Parathyroid hormone-related peptide
Calciotropic
Receptor
Adenylate cyclase
Phospholipase C
Data: 9-Jan-2006
Citação: Canario, A. V. M.; Rotllant, J.; Fuentes, J.; Guerreiro, P. M.; Teodosio, H. R.; Power, D. M.; Clark, M. S.Novel bioactive parathyroid hormone and related peptides in teleost fish, Febs Letters, 580, 1, 291-299, 2006.
Resumo: We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.
Peer review: yes
URI: http://hdl.handle.net/10400.1/3850
DOI: http://dx.doi.org/10.1016/j.febslet.2005.12.023
ISSN: 0014-5793
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0014579305014845#
Aparece nas colecções:CCM2-Artigos (em revistas ou actas indexadas)



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