Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/4382
Título: Warfarin effects in the skeletal development of zebrafish (Danio rerio)
Autor: Peres dos Santos, R.
Bensimon-Brito, A.
Gavaia, Paulo J.
Cancela, Leonor
Data: 2009
Editora: Centre of Marine Sciences
Citação: Peres dos Santos R., Bensimon-Brito A., Gavaia P., Cancela M.L. 2009. Warfarin effects in the skeletal development of zebrafish (Danio rerio). Interdisciplinary Approaches in Fish Skeletal Biology, April 27 – 29 Tavira, Portugal.
Resumo: Vitamin K-dependent gamma carboxylation (VKGC) is crucial for posttranslational modification of glutamate residues to form α-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide (1). This modification has important implications, mainly physiological, like homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and proteins like bone Gla protein (BGP) and matrix Gla protein (MGP), being essential for their biological activity. Warfarin is a known anticoagulant that inhibits the action of VKGC (2), inhibiting consequently the activity of the referred proteins.
Peer review: yes
URI: http://hdl.handle.net/10400.1/4382
Aparece nas colecções:CCM4-Vários

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