Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/4407
Título: Developmental effects of warfin in the skeletogenesis of zebrafish (Danio rerio) larvae
Autor: Peres dos Santos, R.
Brito, A. B.
Cancela, Leonor
Gavaia, Paulo J.
Data: 2008
Editora: Centro de Ciências do Mar
Citação: Peres dos Santos R., Brito A.B., Cancela M.L., Gavaia P.J. 2008. Developmental effects of warfarin in the skeletogenesis of zebrafish (Danio rerio) larvae. Marine Genomics Europe final meeting. CCMAR-University of Algarve May 13-16, Faro, Portugal.
Resumo: The vitamin K-dependent gamma carboxylase (VKGC) is responsible for the post-translational modification of glutamate residues to y-carboxy glumatic acid (Gla), in the presence of the co-factor, vitamin K. This modification has important implications, such as physiological homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and matrix proteins like bone Gla protein (bgp) and matrix Gla protein (mgp), being essential for their biological activity.
Peer review: yes
URI: http://hdl.handle.net/10400.1/4407
Aparece nas colecções:CCM2-Artigos (em revistas ou actas indexadas)



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