Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/5741
Título: Automatic processing of bidimensional images of ''omic'' expression blobs
Autor: Anjos, António dos
Orientador: Shahbazkia, Hamid Reza
Data de Defesa: 2011
Resumo: In this work, a comprehensive review on automatic analysis of Proteomics and Genomics images is presented. Special emphasis is given to a particularly complex image produced by a technique called Two-Dimensional Gel Electrophoresis (2-DE), with thousands of spots (or blobs). Automatic methods for the detection, segmentation and matching of blob like features are discussed and proposed. In particular, a very robust procedure was achieved for processing 2-DE images, consisting mainly of two steps: a) A very trustworthy new approach for the automatic detection and segmentation of spots, based on the Watershed Transform, without any foreknowledge of spot shape or size, and without user intervention; b) A new method for spot matching, based on image registration, that performs well for either global or local distortions. The results of the proposed methods are compared to state-of-the-art academic and commercial products.
URI: http://hdl.handle.net/10400.1/5741
Designação: Doutoramento em Engenharia Informática
Aparece nas colecções:UA01-Teses

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