Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/6454
Título: Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua)
Autor: Custódio, Luísa
Fernandes, Eliana
Escapa, Ana Luísa
López-Avilés, Sandra
Fajardo, Alba
Aligué, Rosa
Alberício, Fernando
Romano, Anabela
Palavras-chave: Cytotoxicity
Flavonoids
HeLa cells
Polyphenols
Reactive oxygen species
Data: 2009
Editora: Taylor & Francis
Resumo: The methanol leaf extracts of female cultivars of the carob tree [Ceratonia siliqua L. (Fabaceae)] and of hermaphrodite and male trees were investigated for their contents of phenolic compounds, their in vitro antioxidant activity, measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging and linoleic acid system assays, and their in vitro tumor growth inhibition on HeLa cells. The different cultivars and trees showed high levels of phenols, and considerable variations in the amount of these compounds. The extracts showed significant radical scavenging activity (RSA), which was not significantly affected by the gender of the tree. From the female cultivars tested, Galhosa exhibited the highest RSA. Gender significantly affected the antioxidant activity of the extracts measured by the linoleic acid system assay, and males and hermaphrodites showed the highest activities. The extracts displayed a remarkable ability to inhibit tumor cell proliferation, and their bioactivity varied with different cultivars or trees tested. Extracts from male and hermaphrodite trees exhibited higher capacity to inhibit the proliferation of HeLa cells than the female cultivars.
Peer review: yes
URI: http://hdl.handle.net/10400.1/6454
DOI: http://dx.doi.org/10.1080/13880200902936891
ISSN: 1388-0209
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)



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