Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/12284
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dc.contributor.authorCosta, Rita-
dc.contributor.authorBrazona, Rute Sofia Tavares Martins-
dc.contributor.authorCapilla, E.-
dc.contributor.authorGuerreiro, Liliana-
dc.contributor.authorPower, Deborah-
dc.date.accessioned2019-01-04T13:17:46Z-
dc.date.available2019-01-04T13:17:46Z-
dc.date.issued2018-12-13-
dc.identifier.citationBMC Evolutionary Biology. 2018 Dec 13;18(1):191pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/12284-
dc.description.abstractBackground Osteoglycin (OGN, a.k.a. mimecan) belongs to cluster III of the small leucine-rich proteoglycans (SLRP) of the extracellular matrix (ECM). In vertebrates OGN is a characteristic ECM protein of bone. In the present study we explore the evolution of SLRP III and OGN in teleosts that have a skeleton adapted to an aquatic environment. Results The SLRP gene family has been conserved since the separation of chondrichthyes and osteichthyes. Few gene duplicates of the SLRP III family exist even in the teleosts that experienced a specific whole genome duplication. One exception is ogn for which duplicate copies were identified in fish genomes. The ogn promoter sequence and in vitro mesenchymal stem cell (MSC) cultures suggest the duplicate ogn genes acquired divergent functions. In gilthead sea bream (Sparus aurata) ogn1 was up-regulated during osteoblast and myocyte differentiation in vitro, while ogn2 was severely down-regulated during bone-derived MSCs differentiation into adipocytes in vitro. Conclusions Overall, the phylogenetic analysis indicates that the SLRP III family in vertebrates has been under conservative evolutionary pressure. The retention of the ogn gene duplicates in teleosts was linked with the acquisition of different functions. The acquisition by OGN of functions other than that of a bone ECM protein occurred early in the vertebrate lineage.pt_PT
dc.description.sponsorshipNational funds through FCT – Foundation for Science and Technology (UID/ Multi/04326/2016).pt_PT
dc.language.isoengpt_PT
dc.publisherBMCpt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/222719/EUpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81625%2F2011/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F66742%2F2009/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F79105%2F2011/PTpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSmall leucine-rich proteoglycan (SLRP) familypt_PT
dc.subjectOsteoglycinpt_PT
dc.subjectMyocytespt_PT
dc.subjectOsteoblastspt_PT
dc.subjectAdipocytespt_PT
dc.subjectTeleostspt_PT
dc.titleVertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fishpt_PT
dc.typearticlept_PT
dc.date.updated2019-01-01T07:33:14Z-
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.rights.holderThe Author(s).-
degois.publication.issue1pt_PT
degois.publication.firstPage191pt_PT
degois.publication.titleBMC Evolutionary Biologypt_PT
dc.peerreviewedyespt_PT
degois.publication.volume18pt_PT
dc.identifier.doihttps://doi.org/10.1186/s12862-018-1310-2pt_PT
dc.identifier.tid202023850-
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