Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3833
Título: Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus
Autor: Cardoso, J. C. R.
Laiz-Carrión, R.
Louro, Bruno
Silva, N.
Canario, Adelino V. M.
Mancera, J. M.
Power, Deborah
Palavras-chave: Ectopic expression
Evolution
Gene duplication
Pituitary
POMC
Sub-functionalization
Data: 2011
Editora: Elsevier
Citação: Cardoso, J.C.R.; Laiz-Carrion, R.; Louro, B.; Silva, N.; Canario, A.V.M.; Mancera, J.M.; Power, D.M. Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus, General and Comparative Endocrinology, 173, 3, 396-404, 2011.
Resumo: Proopiomelanocorticotrophin (POMC) in vertebrates is produced in the pituitary gland and undergoes post-translational processing to give rise to a range of biologically active peptides. Teleosts possess 2–3 different POMC transcripts which have been proposed to have originated from a whole or partial genome duplication. In the present study 2 transcripts of gilthead sea bream POMC (sbPOMC-a1 and a2) were cloned and characterised. sbPOMC-a1 is expressed principally in the melanotroph cells of the pars intermedia (PI) and sbPOMC-a2 is expressed in the corticotroph cells of the rostral pars distalis and probably also in the PI. The 2 sbPOMC transcripts have a differential tissue distribution in extra-pituitary sites. An appraisal of POMC evolution indicates sbPOMCs belong to one of the two main clades that exist in teleosts and that overall a non conservative process of gene loss occurred in this infraclass.
Peer review: yes
URI: http://hdl.handle.net/10400.1/3833
DOI: http://dx.doi.org/10.1016/j.ygcen.2010.12.001
ISSN: 00166480
Aparece nas colecções:CCM2-Artigos (em revistas ou actas indexadas)



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