Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3930
Título: Characterization of a sea bream (Sparus aurata) thyroid hormone receptor-ß clone expressed during embryonic and larval development
Autor: Nowell, M. A.
Power, Deborah
Canario, Adelino V. M.
Llewellyn, Lynda
Sweeney, Glen E.
Data: 2001
Editora: Academic Press
Citação: Nowell, M.A.; Power, D.M.; Canario, A.V.M.; Llewellyn, L.; Sweeney, G.E. Characterization of a Sea Bream (Sparus aurata) Thyroid Hormone Receptor-ß Clone Expressed during Embryonic and Larval Development, General and Comparative Endocrinology, 123, 1, 80-89, 2001.
Resumo: A clone encoding thyroid hormone receptor-b (TR-b) was isolated from a sea bream (Sparus aurata) ovary cDNA library. Sea bream (sb)TR-b is closely related to its counterparts from other vertebrates and, like them, preferentially binds T3 rather than T4. However, the putative sbTR-b protein contains a nine-amino-acid insert that is also present in the corresponding proteins from flounder and salmon but absent in TR-bs from zebrafish and terrestrial vertebrates. Semiquantitative RT–PCR analysis showed that sbTR-b transcripts begin to accumulate during gastrulation and increase markedly in quantity up to the period around hatch (ca. 40 h postfertilization) before declining slightly. In adult tissues, TR-b mRNA was present in approximately equal quantities in heart, intestine, brain, kidney, skeletal muscle, liver, and gill. The significance of the relatively strong expression of TR-b during sea bream embryogenesis is discussed.
Peer review: yes
URI: http://hdl.handle.net/10400.1/3930
DOI: http://dx.doi.uri/10.1006/gcen.2001.7649
ISSN: 0016-6480
Aparece nas colecções:CCM2-Artigos (em revistas ou actas indexadas)

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