Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/6456
Título: Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds
Autor: Custódio, Luísa
Escapa, Ana Luísa
Patarra, João
Aligué, Rosa
Alberício, Fernando
Neng, Nuno Rosa
Nogueira, José Manuel F.
Romano, Anabela
Palavras-chave: Antioxidant activity
Cytotoxic
Gentisic acid
Phenolic compounds
ROS
Data: 2013
Editora: ACG Publications
Resumo: Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.
Peer review: yes
URI: http://hdl.handle.net/10400.1/6456
ISSN: 1307-6167
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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