Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/7403
Título: Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging
Autor: Mouffouk, Fouzi
Dornelle, Daniel
Lopes, André D.
Martins, Jorge
Abu-Salah, Khalid
Costa, Ana M. Rosa da
dos Santos, Nuno
Sau, Pablo
Simão, Teresa
Alrokayan, Salman A.
Palavras-chave: Micelle
Smart contrast agent
Cancer detection
Data: 2014
Editora: American Society for Nanomedicine
Citação: Int. J. Nanomedicine (2015) 10, 63-76
Resumo: Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol-b-trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ((t)BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that (t)BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35-40 nm) reveals their potential use for early cancer detection by MRI.
Peer review: yes
URI: http://hdl.handle.net/10400.1/7403
DOI: 10.2147/IJN.S71190
ISSN: 1176-9114
Versão do Editor: http://www.dovepress.com/self-assembled-polymeric-nanoparticles-as-new-smart-contrast-agents-fo-peer-reviewed-article-IJN
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