Simes, DGavaia, Paulo J.Ortiz-Delgado, J. B.Pinto, JorgeCancela, Leonor2014-06-192014-06-192001Simes, D.C., Gavaia, P.J., Pinto, J.P., Cancela, M.L. 2001. Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates. Bone, 28 (5) S103, P10.AUT: LCA00739; AUT: DSI00813http://hdl.handle.net/10400.1/4426Osteocalcin (BGP or Bone Gla protein) is a small acidic protein with 46-50 residues (pI»4.0) that belongs to the family of the vitamin K dependent, Gla containing proteins. This protein is the most abundant non-collagenous bone protein in mammals and has been isolated only from bone and dentine suggesting that it may be expressed only in hydroxyapatite-containing bone tissue. Previous studies suggest that in mammals BGP is an ossification regulator, but its mode of action at the molecular level, in particular in non-mammalian organisms, remains unclearengjournal article2014-05-30