Oliveira, Ana V.Marcelo, AdrianaCosta, Ana M. Rosa daSilva, Gabriela A.2016-01-112016-01-112016Mater. Sci. Eng. C, 58, 2016, 264–2720928-4931AUT: GAS02236; AMC01695;http://hdl.handle.net/10400.1/7408A successful gene therapy approach can prevent or treat congenital and acquired diseases. However, there is still no ideal non-viral vector for gene delivery in a safe and timely manner. In this report the anionic polymer hyaluronic acid (HA) was investigated as a potential vector for gene therapy. Due to its intrinsic characteristics it constitutes an excellent candidate to deliver therapeutic genes, pending the modification of its surface charge.engGene therapyHyaluronic acidPolymer modificationRetinaBiocompatibilityjournal articlehttp://dx.doi.org/ 10.1016/j.msec.2015.08.047