S B Viegas, CarlaSimes, D2020-07-272020-07-272019http://hdl.handle.net/10400.1/14522Management and prevention of cardiovascular disease (CVD) represents one of the major health challenges worldwide. CVD is the leading cause of death globally despite all research efforts on last decades regarding the molecular mechanisms and processes involved on its development and progression. Chronic Kidney Disease (CKD) is an independent risk factor and promotor of CVD events, representing a considerable economic cost for the health system. CVD is the leading cause of death in all CKD stages, accounting for half the number of deaths in this population.engBiomarkersGene expression regulationHumansIntracellular signaling peptides and proteinsVascular calcificationjournal article10.18632/aging.101851