Duarte, Ana JoanaRibeiro, DiogoSantos, RenatoMoreira, LucianaBragança, JoséAmaral, Olga2020-09-032020-09-0320201873-5061http://hdl.handle.net/10400.1/14676Fabry Disease (FD) is a multisystemic X-linked disorder that belongs to the group of lysosomal storage disorders (LSDs). Causal mutations on alpha-galactosidase A (α-Gal A) commonly lead to abnormal protein and consequently to FD. Since it is an X-linked disease, males are primarily affected. This work describes the generation of induced Pluripotent Stem Cells (iPSCs) from skin fibroblasts from a FD patient, using non-integrative episomal vectors. Differentiation of iPSCs can be applied to generate a variety of cell types with high degree of genetic complexity that would otherwise be difficult to obtain.engjournal article10.1016/j.scr.2020.101794