Aureliano, ManuelMitchell, Scott G.Yin, Panchao2022-12-192022-12-1920222296-2646http://hdl.handle.net/10400.1/18666The biomedical application of metals, including platinum (Pt), lithium (Li), tungstate (W), gold (Au) or vanadium (V), among others, has become an important and a rapidly growing branch of science (Bertinat et al., 2018; Yeo et al., 2018; Vosahlikova et al., 2020; Ścibior et al., 2020; Silva et al., 2021; Pena et al., 2022; Ochoa, 2022). Besides the wellcharacterized platinum drugs, bio-active metal-based complexes and clusters, such as gold compounds and polyoxometalates (POMs), as well as metal-based nanoparticles have shown demonstrable anti-cancer, anti-viral and anti-bacterial activities (Bertinat et al., 2018; Yeo et al., 2018; Soria-Carrera et al., 2020; Vosahlikova et al., 2020; Ścibior et al., 2020; Silva et al., 2021; Aureliano et al., 2022a; Pena et al., 2022; Ochoa, 2022; Soria Carrera et al., 2022). The biological and biomedical application of POMs–in the form of cluster ions, hybrid materials, and POM-based nanoparticles - has tripled in the last decade (Pimpão et al., 2020).engPolyoxometalatesAntibacterialAntiviralAntidiabeticBiosensorsMolecular modulations simulationsjournal article10.3389/fchem.2022.977317