Moyano, EncarnacionSantos, JavierNúñez, OscarDaniel, Christy Sarmiento2018-07-022018-07-022010-02-192010http://hdl.handle.net/10400.1/10741In this work, the standard procedures required for the operation, verification and maintenance of a liquid chromatography coupled to mass spectrometry system have been developed. These procedures have been designed and prepared with the aim to establish a quality control system to ensure the proper functioning of each component of the instrumentation, the LC and the MS, and to verify the performance of the LC-MS coupling. For this purpose, standard procedures were elaborated and proved in the normal routine laboratory work to evaluate their real applicability. Moreover, the verification of the performance of the LC-MS system was carried out experimentally through an in-house procedure based on the analysis of naphthylacetics.engLC--MS systemQuality controlmaster thesis