Adashek, Jacob JAguiar, Pedro NCastelo-Branco, PedroLopes, Gilberto LDe Mello, Ramon Andrade2019-11-132019-11-1320191479-6694http://hdl.handle.net/10400.1/12884Breast cancer is a very important disease in terms of public health worldwide. Several patients are diagnosed and follow to a progressive disease every year. CDK4/6 inhibitors (CDKi) were a paradigm shift in the treatment of hormone receptor-positive (HR+), HER2-negative advanced breast cancer (aBC).engAntineoplastic combined chemotherapy ProtocolsBreast neoplasmsClinical trials, Phase II as topicClinical Trials, Phase III as topicFemaleHumansTreatment outcomejournal article10.2217/fon-2019-0044