Laizé, VincentGavaia, Paulo J.S B Viegas, CarlaCancela, Leonor2014-06-252014-06-252006Laizé, V., Gavaia, P.J., Viegas, C.S.B., Cancela, M.L. 2006. Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods. 28th Annual Meeting of the ASBMR, September 15-19, Philadelphia, USA. In: Journal of bone and Mineral Research 21:S338.AUT: LCA00739;http://hdl.handle.net/10400.1/4506The evolution of calcified tissues is a defining feature in vertebrate evolution. Investigating evolution of proteins involved in tissue calcification should help elucidate how calcified tissues have evolved. Osteocalcin (OC) is a small calcium-binding protein accumulated exclusively in bone and teeth, whose function, although essential for tissue calcification, remains unclear. Until recently, only a single osteocalcin isoform had been described (OC I).engconference object2014-05-30