Galay-Burgos, M.Power, DeborahLlewellyn, LyndaSweeney, Glen E.2014-10-242014-10-242007Malyka Galay-Burgos, Deborah M. Power, Lynda Llewellyn, Glen E. Sweeney, "Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)" in Molecular and Cellular Endocrinology 281, 1-2 (2007) 56.0303-7207AUT: DPO00386;http://hdl.handle.net/10400.1/5486Flatfish such as the Atlantic halibut (Hippoglossus hippoglossus) undergo a dramatic metamorphosis that transforms the pelagic, symmetric larva into a benthic, cranially asymmetric juvenile. In common with amphibian metamorphosis, flatfish metamorphosis is under endocrine control with thyroid hormones being particularly important. In this report we confirm that tri-iodothyronine (T3) levels peak at metamorphic climax during halibut metamorphosis. Moreover we have isolated cDNA clones of TR and TR genes and confirmed the presence in halibut of two TR isoforms (representing the products of distinct genes) and two TR isoforms (generated from a single gene by alternative splicing). Real time PCR was used to assess expression of these genes during metamorphosis. TR shows the most dramatic expression profile, with a peak occurring during metamorphic climax.engjournal articlehttp://dx.doi.org/10.1016/j.mce.2007.10.009