Cardoso, Ana LúciaGimeno, LourdesLemos, A.Palacios, FranciscoMelo, Teresa M. V. D. Pinho e2014-12-152014-12-152013-06-21Cardoso, Ana Lúcia; Gimeno, Lourdes; Lemos, Américo; Palacios, Francisco; Pinho e Melo, Teresa M. V. D. The Neber Approach to 2-(Tetrazol-5-yl)-2H-Azirines , The Journal of Organic Chemistry, 78, 14, 6983-6991, 2013.0022-3263AUT: ALE01411http://hdl.handle.net/10400.1/5688The synthesis of 2-(tetrazol-5-yl)-2H azirines is reported for the first time. Using the Neber approach, β-ketoxime-1H-tetrazoles were converted into the target 2Hazirines bearing phenyl, furan-2-yl, thiophen-2-yl, or pyrrol-2-yl substituents at C-3. It was demonstrated that the alkaloidmediated Neber reaction allows the asymmetric synthesis of 2-(tetrazol-5-yl)-2H-azirines.engjournal article2014-12-11http://dx.doi.org/10.1021/jo4006552