Alves, ClaudiaGrosso, CarlaBarrulas, PedroPaixao, Jose A.Cardoso, Ana L.Burke, Anthony J.Lemos, AmericoPinho e Melo, Teresa M. V. D.2021-06-242021-06-242020-040936-5214http://hdl.handle.net/10400.1/16529A successful one-pot methodology for the synthesis of chiral 2-tetrazolyl-2H-azirines has been established, resorting to organocatalysis. The protocol involves the in situ tosylation of beta-ketoxime-1H-tetrazoles followed by the Neber reaction, in the presence of chiral organocatalysts. Among the organocatalysts studied a novel thiourea catalyst derived from 6 beta-aminopenicillanic acid afforded excellent enantioselectivities.eng2H-azirinesasymmetric Neber reactionorganocatalysistetrazolesthiourea6 beta-aminopenicillanic acidChemistryAsymmetric neber reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirinesjournal article10.1055/s-0039-1691533