Mendes, FilipaGomes, AnaAlonso, IsisFragoso, AndréPereira, Luisa HelenaJerónimo, TeresaPimentel, AnaNeves, Pedro L.2017-04-072017-04-072016-050931-0509AUT: PGS02043;http://hdl.handle.net/10400.1/9496In the Western World the general population is getting older. This implies a higher prevalence of osteoporosis as well as a greater incidence of patients with chronic kidney disease. These two conditions increase the riskof bone fractures. Metabolic and hormonal disarrangement in end-stage renal disease (ESRD) negativelyaffects bone remodeling as it promotes a decrease in Vitamin D availability, hyperphosphatemia, hypocalcemia, high secretion of parathormone and chronic metabolic acidosis. The NHANES III showed that even moderate-to-severe CKD patients may present with a significant increased riskoffracturewhich is justified by hyperparathyroidism at the earlystages of the disease.engjournal articlehttps://doi.org/10.1093/ndt/gfw190.36