Lopes, Susana M. M.Brigas, AmadeuPalacios, FranciscoLemos, A.Melo, Teresa M. V. D. Pinho e2012-04-182012-04-182012Lopes, Susana M. M.; Brigas, Amadeu F.; Palacios, Francisco; Lemos, A.; Melo, Teresa M. V. D. Pinho e. [4+2] Cycloadditions of 3-Tetrazolyl-1,2-diaza-1,3-butadienes: synthesis of 3-Tetrazolyl-1,4,5,6-tetrahydropyridazines. European Journal of Organic Chemistry, 2012, 11, 2152-2160, 2012.1434193XAUT: ABR00608; ALE01411;http://hdl.handle.net/10400.1/1045The synthesis of new 3-tetrazolyl-1,4,5,6-tetrahydropyridazines by Diels–Alder reactions of ethyl 3-(tetrazol-5-yl)-1,2- diaza-1,3-butadiene-1-carboxylates is reported. These 1,2- diaza-1,3-dienes reacted with electron-rich heterocycles, nucleophilic olefins and cumulenes, as well as with electrondeficient dienophiles, to give the target compounds regioselectively. Computational studies corroborated the rationalization of the observed reactivity and selectivity.engHeterocyclesAza-Diels-alderAzoalkenePyridazinejournal article2012-04-13