Canario, Adelino V. M.Rotllant, J.Fuentes, J.Guerreiro, P. M.Teodósio, H. R.Power, DeborahClark, M. S.2014-05-122014-05-122006-01-09Canario, A. V. M.; Rotllant, J.; Fuentes, J.; Guerreiro, P. M.; Teodosio, H. R.; Power, D. M.; Clark, M. S.Novel bioactive parathyroid hormone and related peptides in teleost fish, Febs Letters, 580, 1, 291-299, 2006.0014-5793AUT: ACA00258; DPO00386;http://hdl.handle.net/10400.1/3850We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.engParathyroid hormoneParathyroid hormone-related peptideCalciotropicReceptorAdenylate cyclasePhospholipase Cjournal article2014-05-09http://dx.doi.org/10.1016/j.febslet.2005.12.023