El Yaagoubi, MohamedOrtiz, SergioMechqoq, HichamCavaleiro, CarlosLecso-Bornet, MarylinRodrigues, Maria JoaoCustódio, LuísaEl Mousadik, AbdelhamidGrougnet, RaphaelEl Aouad, NoureddineMsanda, FouadKritsanida, Marina2021-09-082021-09-082021-061612-1872http://hdl.handle.net/10400.1/16963The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gomiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07 +/- 0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), alpha-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 mu g/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 mu g/mL.engChiliadenus antiatlanticusEssential oilCamphorIntermedeolAntibacterial activityBiochemistry & Molecular Biology; Chemistryjournal article10.1002/cbdv.202100115