Verissimo, EditeBerry, NeilGibbons, Peter D.Cristiano, Maria Lurdes SantosRosenthal, Philip J.Gut, JiriWard, Stephen A.O'Neill, Paul M.2014-06-062014-06-062008Verissimo, Edite; Berry, Neil; Gibbons, Peter; Cristiano, M. Lurdes S.; Rosenthal, Philip J.; Gut, Jiri; Ward, Stephen A.; O’Neill, Paul M. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors, Bioorganic & Medicinal Chemistry Letters, 18, 14, 4210-4214, 2008.0960-894XAUT: MCR00716;http://hdl.handle.net/10400.1/4221The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.engMalariaPlasmodium falciparumCysteine proteaseFalcipain-2Peptidomimeticjournal article2014-06-05http://dx.doi.org/10.1016/j.bmcl.2008.05.068