Medeiros, Maria C. R.Mestre, Ana L. G.INÁCIO, PEDROSantos, João M. L.Araújo, InêsBragança, JoséBiscarini, FabioGomes, Henrique L.2017-04-072017-04-072016978-1-5106-0280-90277-786Xhttp://hdl.handle.net/10400.1/9670Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are used to record extracellular signals from autonomous cardiac contractile cells and glioma cell cultures. The performance of these conducting polymer electrodes is compared with Au electrodes. A small-signal impedance analysis shows that in the presence of an electrolyte, both Au and polymer electrodes establish high capacitive double-layers. However, the polymer/electrolyte interfacial resistance is 3 orders of magnitude lower than the resistance of the metal/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. However, when measurements are carried out in current mode a low interfacial resistance partially acts as a short circuit of the interfacial capacitance, this affects the signal shape.engjournal article10.1117/12.2237659