Liberti, DavideImbimbo, PaolaGiustino, EnricaD’Elia, LuigiSilva, MélanieBarreira, LuísaMonti, Daria Maria2023-02-272023-02-272023-01-31Antioxidants 12 (2): 337 (2023)http://hdl.handle.net/10400.1/19131Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.engMicroalgaeExopolysaccharidesPhycoerythrinAntioxidant activityAnti-inflammatory activityBiocompatibilityWound healingjournal article2023-02-2410.3390/antiox120203372076-3921