Kumar, GirishJain, PushpikaVirmani, TarunSharma, AshwaniAkhtar, Md SayeedAldosari, Saad AKhan, Mohd FaiyazDuarte, Sofia O DFonte, Pedro2026-05-072026-05-072024-092041-5990http://hdl.handle.net/10400.1/28887Apigenin, a poten t na tural flav onoid , has emerged as a key therapeutic agent due to its multifac et ed medicinal properties in combating various diseases. How ev er, apigenin’s clinical utility is greatly limited by its poor w a ter solubility, low bioav ailabilit y and stabilit y issues. To address these challenges, this review paper explores the innov a tive field of nanotechnology-based delivery sy st ems, which have shown significant promise in improving the delivery and effectiveness of apigenin. This paper also explores the synerg istic pot ential of c o-delivering apigenin with conventional therapeutic agents. Despite the advantageous properties of these nanoformulations, critical challenges such as scalable pr oduction, r egulatory appr ovals and compr ehensiv e long-term safety assessments remain key hurdles in their clinical adoption which must be addressed for commercialization of apigenin-based formulations.engApigeninBioavailabilityFlavonoidNanocarriersPolymersStabilityTherapeuticsjournal article10.1080/20415990.2024.23869282041-6008