Sousa, Helena Tavaresde Oliveira, Raquel2026-04-132026-04-132025-02-132050-6406http://hdl.handle.net/10400.1/28650Fibrosis is a serious complication of both Crohn's disease (CD) and ulcerative colitis(UC) and is currently the major unmet need in inflammatory bowel disease (IBD) management [1]. Although much less prevalent in UC, strong evidence supports severity and chronicity of inflammation are the main drivers of excessive extracellular matrix (ECM) deposition in the submucosa and muscularis mucosae [2], leading to increased wall stiffness, and ultimately to motility and anorectal dysfunction, rectal urgency and incontinence.engeditorial10.1002/ueg2.127702050-6414