Silva, Ana PaulaMendes, FilipaCarias, EduardaBaptista Gonçalves, RuiFragoso, AndréDias, CarolinaTavares, NelsonMendonça Café, HugoSantos, NélioRato, FátimaNeves, Pedro LeãoAlmeida, Edgar2019-05-032019-05-0320191422-0067http://hdl.handle.net/10400.1/12480Research over the past decade has focused on the role of Klotho as a cardio protective agent that prevents the effects of aging on the heart and reduces the burden of cardiovascular disease CVD. The role of the interaction between fibroblast growth factor 23-(FGF-23)/Klotho in Klotho-mediated actions is still under debate. The main objective was to ascertain the potential use of plasmatic Klotho and FGF23 as markers for CKD-associated cardiac disease and mortality.engKlothoFGF-23CKDCVDLVMIjournal article10.3390/ijms20071536