Rodrigues, Maria João2026-03-112026-03-112024-12-202223-7747http://hdl.handle.net/10400.1/28406The exploration of natural products derived from medicinal plants that provide an abundance of bioactive compounds has long been a cornerstone of scientific discovery, revolutionizing fields such as medicine, agriculture, and biotechnology [1]. Notable examples include artemisinin, a life-saving antimalarial derived from Artemisia annua [2], and taxol, a chemotherapeutic agent sourced from the Pacific yew tree [3], both of which highlight the immense potential of medicinal plants to address global health challenges. Over the past decade, rapid advancements in analytical techniques, omics technologies, and bioinformatics have significantly improved our ability to uncover and characterize these natural products. Despite these strides, critical challenges persist in the field, including the sustainable utilization of plant resources, the discovery of novel compounds with unique modes of action, and the translation of these findings into practical, real-world applications. This Special Issue, Bioprospecting of Natural Products from Medicinal Plants, highlights the vast potential of medicinal plants as reservoirs of bioactive compounds. Comprising twelve articles—an inspiring blend of original research and review papers—this collection exemplifies the collaborative spirit of researchers across Europe, Asia, Africa, and the Americas. The global significance of medicinal plant research is further emphasized by the diverse contributions, which reflect the unique biodiversity and ecological challenges faced by different regions. Such international collaboration is vital, as each country brings its distinctive resources and expertise to uncovering and harnessing new bioactive compounds.engjournal article10.3390/plants13243556