de Castro, Karine CappuccioCoco, Julia Cedrandos Santos, Érica MendesAtaide, Janaína ArtemMartinez, Renata Milianido Nascimento, Mônica Helena MonteiroPrata, JoãoFonte, PedroSeverino, PatríciaMazzola, Priscila GavaBaby, André RolimSouto, Eliana Barbosade Araujo, Daniele RibeiroLopes, André Moreni2023-03-032023-03-0320230168-3659http://hdl.handle.net/10400.1/19196This paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects.engPluronic?Amphiphilic copolymersSelf-assemblyDrug delivery systems (DDS)Nanostructures (NSs)Cancer therapyjournal article10.1016/j.jconrel.2022.12.017