Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Parente Carvalho, CatiaNorouzy, AmirRibeiro, VeraNau, Werner M.Pischel, Uwe2018-12-072018-12-072015-031477-05201477-0539http://hdl.handle.net/10400.1/11632Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.engMolecular ContainersAmino-AcidsSynthetic ReceptorMass-SpectrometryPk(A) ShiftsPeptidesBindingRecognitionDrugsThermodynamicsCucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleasesjournal article10.1039/c4ob02122c