Gago, CustódiaBakchiche, BoulanouarDjekhioua, TaharMiguel, Maria da Graça2025-12-222025-12-222025-11-161420-3049http://hdl.handle.net/10400.1/28004Cistus ladanifer L., commonly known as gum rockrose, is a Mediterranean shrub of growing interest due to its valuable essential oils (EOs) and labdanum resin. This review synthesizes current knowledge on the chemical composition and biological activities of EOs and hydrolates from C. ladanifer across Mediterranean regions, with particular emphasis on Spain, Portugal, Morocco, and France. α-Pinene, viridiflorol, and camphene were found to be the major constituents in the EOs with antioxidant and antimicrobial properties. Additionally, the identified biological properties have prompted studies exploring innovative strategies such as nanoparticle encapsulation, the development of bioactive films, and the incorporation of EOs into food and pharmaceutical packaging. By-products from EO distillation, including lignocellulosic residues, the extraction of phenolic-rich compounds, and hydrolates, have shown potential for value-added applications. Altogether, C. ladanifer represents a versatile species with possible applications in cosmetics, pharmaceutical development, and the food industry.engRockroseLabdanumEssential oilsAntimicrobialAntioxidantHerbicidal propertiesCytotoxicityBioactive by-productsjournal article10.3390/molecules30224425