Silva, José P. daChoudhury, RajibPorel, MintuPischel, UweJockusch, SteffenHubbard, PeterRamamurthy, VaidhyanathanCanario, Adelino V. M.2014-09-182014-09-182014-05-19José P. Da Silva, Rajib Choudhury, Mintu Porel, Uwe Pischel, Steffen Jockusch, Peter C. Hubbard,Vaidhyanathan Ramamurthy, and Adelino V. M. Canário. 2014, Synthetic versus natural receptors: supramolecular control of chemical sensing in fish, ACS Chemical Biology, 9, 1432-1436, dx.doi.org/10.1021/cb500172u1554-8929AUT: ACA00258;http://hdl.handle.net/10400.1/4978The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.engSyntheticNatural receptorsSupramolecular controlFishjournal articlehttp://dx.doi.org/10.1021/cb500172u |