Rodríguez de Santiago, Enriquede la Iglesia, Sandra Pérezde Frutos, DiegoMarín-Gabriel, José CarlosMangas-SanJuan, CarolinaHonrubia López, RaúlUchima, HugoAicart-Ramos, MartaRodríguez Gandía, Miguel ÁngelValdivielso Cortázar, EduardoZabala, Felipe RamosÁlvarez, Marco AntonioSolano Sánchez, MarinaGonzález Santiago, Jesús ManuelAlbéniz, EduardoHijos-Mallada, GonzaloQuismondo, Nerea CastroFraile-López, MiguelMartínez Ares, DavidTejedor-Tejada, JavierHernández, LuisGornals, Joan B.Quintana-Carbo, SergiOcaña, JuanNeves, João A. CunhaMartínez Martínez, JuanPinilla, María López-CerónAbadía, Carlos DolzPellisé, María2025-06-252025-06-252025-041756-2848http://hdl.handle.net/10400.1/27275Background: Delayed post-polypectomy bleeding (DPPB) is the most common adverse event following colonic polypectomy, yet its management remains highly heterogeneous and lacks standardization. A considerable number of colonoscopies performed for DPPB may be unnecessary and do not result in hemostatic intervention.Objectives: To develop evidence-based statements to guide clinical decision-making in DPPB.Design: Multidisciplinary Delphi consensus statement.Methods: A panel of 29 experts in gastroenterology, hematology, radiology, and surgery was assembled. Through a systematic review of the literature and a modified Delphi process, consensus statements were developed through iterative rounds of anonymous voting. Statements were revised following anonymous voting and feedback at each round. Those achieving 80% agreement were accepted.Results: The expert panel reached a consensus on 36 statements, covering areas such as antithrombotic management, bowel preparation, colonoscopy indications, and therapeutic hemostatic modalities. Key recommendations include guidance for managing self-limited bleeding and risk stratification to reduce the rate of unnecessary colonoscopies, as well as recommendations for hemodynamically unstable patients who may require primary angioembolization. A practical clinical algorithm is proposed.Conclusion: This document provides a consensus-based framework for managing DPPB. These recommendations aim to improve patient outcomes and optimize healthcare resources while fostering a standardized approach to this common adverse event.engColonic polypsColonoscopyHemorrhagePolypectomyjournal article10.1177/175628482513291451756-2848