Grosso, CarlaCardoso, Ana L.Rodrigues, Maria JoaoMarques, CatiaBarreira, LuísaLemos, AmericoPinho e Melo, Teresa M. D. V.2019-11-202019-11-202017-020968-08961464-3391http://hdl.handle.net/10400.1/13234A novel synthetic approach to bis(indolyl)methanes has been established. Our one-pot synthetic strategy based on two consecutive hetero-Diels-Alder cycloaddition reactions of electrophilic conjugated nitrosoalkenes with indoles was extended to a range of new 1-hydroxyiminomethyl-bis(indolyl) methanes. Furthermore, a similar and broad range approach was applied to the synthesis of previously unknown 1-hydrazonomethyl-bis(indolyl)methanes. The biological evaluation of the new bis(indolyl) methanes as anti-cancer agents was investigated. (C) 2016 Elsevier Ltd. All rights reserved.engFriedel-crafts reactionsEnantioselective synthesisBis-indolylmethanesRecyclable catalystCarbonyl-compoundsTerminal alkynesIndolesDerivativesNitrosoalkenesActivationjournal article10.1016/j.bmc.2016.12.028