Inácio, PedroMestre, Ana L GMedeiros, C.R.Asgarifar, SanazELAMINE, YoussefCanudo, JoanaSantos, JoãoBragança, JoséMorgado, JorgeBiscarini, FabioGomes, Henrique L.2019-11-202019-11-202017-071530-437X1558-1748http://hdl.handle.net/10400.1/13084Conducting polymer electrodes based on poly (3, 4 ethylenedioxythiophene): polystyrene sulfonate were used to record electrophysiological signals from autonomous cardiac contractile cells present in embryoid bodies. Signal detection was carried out by measuring the displacement current across the polymer/electrolyte double-layer capacitance, and compared with voltage detection. While for relatively low capacitance electrodes, the voltage amplification provides higher signal quality, and for high capacitive electrodes, the displacement current method exhibits a higher signal-to-noise ratio. It is proposed that the displacement current method combined with high capacitive polymer-based electrodes is adequate to measure clusters of cells and whole organs. Our approach has a great potential in fundamental studies of drug discovery and safety pharmacology.engEmbryonic Stem-CellsMicroelectrode ArraysTechnologyChipsjournal article10.1109/JSEN.2017.2703834