Peres dos Santos, R.Brito, A. B.Cancela, LeonorGavaia, Paulo J.2014-06-192014-06-192008Peres dos Santos R., Brito A.B., Cancela M.L., Gavaia P.J. 2008. Developmental effects of warfarin in the skeletogenesis of zebrafish (Danio rerio) larvae. Marine Genomics Europe final meeting. CCMAR-University of Algarve May 13-16, Faro, Portugal.AUT: LCA00739http://hdl.handle.net/10400.1/4407The vitamin K-dependent gamma carboxylase (VKGC) is responsible for the post-translational modification of glutamate residues to y-carboxy glumatic acid (Gla), in the presence of the co-factor, vitamin K. This modification has important implications, such as physiological homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and matrix proteins like bone Gla protein (bgp) and matrix Gla protein (mgp), being essential for their biological activity.engconference object