Maciel, RitaPalma, RaquelSousa, PedroFerreira, FatimaNzwalo, Hipólito2018-12-072018-12-072015-012287-63912287-6405http://hdl.handle.net/10400.1/11361Concomitant occurrence of acute myocardial infarction (MI) and stroke is infrequently encountered in emergent patients. Acute MI within the previous 3 months is considered a relative contraindication for therapy with alteplase or intravenous tissue plasminogen activator (IV rtPA).1 The use of IV rtPA for stroke in patients with a recent MI is associated with an increased risk of cardiac rupture, secondary to breakdown of the existing fibrin clot within the necrotic myocardium and/or degradation of collagen2 . Whether it is appropriate to perform thrombolysis in an emergent patient with concomitant ischemic stroke and MI remains a matter for debate.engCardiac ruptureTherapyother10.5853/jos.2015.17.1.84