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Phenolic profile, toxicity, enzyme inhibition, in silico studies, and antioxidant properties of cakile maritima Scop. (Brassicaceae) from southern portugal

2020-01-22Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorPlacines, Chloé
dc.contributor.authorCastañeda-Loaiza, Viana
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorGuerreiro Pereira, Catarina Alexandra
dc.contributor.authorStefanucci, Azzurra
dc.contributor.authorMollica, Adriano
dc.contributor.authorZengin, Gokhan
dc.contributor.authorLlorent-Martínez, Eulogio J.
dc.contributor.authorCastilho, Paula C.
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2026-02-26T11:59:05Z
dc.date.available2026-02-26T11:59:05Z
dc.date.issued2020-01-22
dc.description.abstractCakile maritima Scop. (sea rocket) is an edible halophyte plant with several ethnomedicinal uses. This work reports the chemical profile and bioactivities of food grade extracts from sea rocket organs. Toxicity was determined on mammalian cells, and phenolic profiling and the quantitation of the main metabolites were made by high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Enzymatic inhibition was determined towards acetyl- and butyrylcholinesterase (AChE, BuChE), α-glucosidase, α-amylase, and tyrosinase. Docking studies were performed to tyrosinase, on the major metabolites, and samples were tested for antioxidant properties. Extracts were not toxic, were constituted mainly by flavonoids, and some compounds (roseoside and oleuropein) are here described for the first time in the species. The aerial organs’ ethanol extract had relevant activity towards 2,2-diphenyl-1-picrylhydrazyl [DPPH, half maximal inhibitory concentration (IC50) = 0.59 mg/mL], and ferric-reducing activity power (FRAP, IC50 = 0.99 mg/mL). All samples were more active towards AChE than on BuChE. The ethanol fruits’ extract inhibited α-glucosidase [2.19 mmol of equivalent of acarbose (ACAE)/g]. Samples were active against tyrosinase, especially the aerial organs’ ethanol extracts [25.9 mg of equivalent of kojic acid (KAE)/g]. Quercetin and kaempferol glycosides fit well into the enzymatic pocket of tyrosinase. Our results suggest sea rocket as a candidate to be further explored as a source of bioactive products.eng
dc.description.sponsorshipCCMAR/Multi/04326/2019; ALG-01-0145-FEDER-028876; CEECIND/00425/2017
dc.identifier.doi10.3390/plants9020142
dc.identifier.issn2223-7747
dc.identifier.urihttp://hdl.handle.net/10400.1/28262
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationResearch Institute for Medicines
dc.relationUnravelling the biotechnological potential of halophyte species from the Algarve coast - HaloBiotech
dc.relation.ispartofPlants
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioactive plant-derived products
dc.subjectTyrosinase inhibitors
dc.subjectSalt tolerant plants
dc.titlePhenolic profile, toxicity, enzyme inhibition, in silico studies, and antioxidant properties of cakile maritima Scop. (Brassicaceae) from southern portugaleng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleUnravelling the biotechnological potential of halophyte species from the Algarve coast - HaloBiotech
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F116604%2F2016/PT
oaire.citation.issue2
oaire.citation.startPage142
oaire.citation.titlePlants
oaire.citation.volume9
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePlacines
person.familyNameCastañeda-Loaiza
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameChloé
person.givenNameViana
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2319-B2D8-AF48
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8550-5099
person.identifier.orcid0000-0002-8839-1389
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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