Publication
Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
| dc.contributor.author | Viegas, Cláudia | |
| dc.contributor.author | Patrício, Ana B. | |
| dc.contributor.author | Prata, João M. | |
| dc.contributor.author | Nadhman, Akhtar | |
| dc.contributor.author | Chintamaneni, Pavan Kumar | |
| dc.contributor.author | Fonte, Pedro | |
| dc.date.accessioned | 2023-06-28T09:35:02Z | |
| dc.date.available | 2023-06-28T09:35:02Z | |
| dc.date.issued | 2023-05-25 | |
| dc.date.updated | 2023-06-27T13:21:49Z | |
| dc.description.abstract | Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier | doi: 10.3390/pharmaceutics15061593 | |
| dc.identifier.citation | Pharmaceutics 15 (6): 1593 (2023) | pt_PT |
| dc.identifier.doi | 10.3390/pharmaceutics15061593 | pt_PT |
| dc.identifier.issn | doi: 10.3390/pharmaceutics15061593 | |
| dc.identifier.issn | doi: 10.3390/pharmaceutics15061593 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/19772 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | Algarve Centre for Marine Sciences | |
| dc.relation | Algarve Centre for Marine Sciences | |
| dc.relation | Institute for Bioengineering and Biosciences | |
| dc.relation | Institute for Bioengineering and Biosciences | |
| dc.relation | Antibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment | |
| dc.relation | Institute for Health and Bioeconomy | |
| dc.relation | Centre for Marine and Environmental Research | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Algarve Centre for Marine Sciences | |
| oaire.awardTitle | Algarve Centre for Marine Sciences | |
| oaire.awardTitle | Institute for Bioengineering and Biosciences | |
| oaire.awardTitle | Institute for Bioengineering and Biosciences | |
| oaire.awardTitle | Antibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment | |
| oaire.awardTitle | Institute for Health and Bioeconomy | |
| oaire.awardTitle | Centre for Marine and Environmental Research | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/OE/2020.08839.BD/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT | |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 1593 | pt_PT |
| oaire.citation.title | Pharmaceutics | pt_PT |
| oaire.citation.volume | 15 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | OE | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Mestre Viegas | |
| person.familyName | Fonte | |
| person.givenName | Cláudia Sofia | |
| person.givenName | Pedro | |
| person.identifier.ciencia-id | BC13-CBFD-ECA6 | |
| person.identifier.ciencia-id | 2410-123D-3385 | |
| person.identifier.orcid | 0000-0001-6668-2778 | |
| person.identifier.orcid | 0000-0002-1115-9282 | |
| person.identifier.rid | K-3215-2013 | |
| person.identifier.scopus-author-id | 55146900200 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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