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Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish

2024-07-29Journal article Open access
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dc.contributor.authorChen, Jie
dc.contributor.authorZhao, Wenting
dc.contributor.authorCao, Lei
dc.contributor.authorMartins, Rute Sofia Tavares
dc.contributor.authorCanario, Adelino
dc.date.accessioned2024-09-28T10:07:17Z
dc.date.available2024-09-28T10:07:17Z
dc.date.issued2024-07-29
dc.description.abstractBackgroundEnergy allocation between growth and reproduction determines puberty onset and fertility. In mammals, peripheral hormones such as leptin, insulin and ghrelin signal metabolic information to the higher centres controlling gonadotrophin-releasing hormone neurone activity. However, these observations could not be confirmed in lower vertebrates, suggesting that other factors may mediate the energetic trade-off between growth and reproduction. A bioinformatic and experimental study suggested co-regulation of the circadian clock, reproductive axis and growth-regulating genes in zebrafish. While loss-of-function of most of the identified co-regulated genes had no effect or only had mild effects on reproduction, no such information existed about the co-regulated somatostatin, well-known for its actions on growth and metabolism.ResultsWe show that somatostatin signalling is pivotal in regulating fecundity and metabolism. Knock-out of zebrafish somatostatin 1.1 (sst1.1) and somatostatin 1.2 (sst1.2) caused a 20-30% increase in embryonic primordial germ cells, and sst1.2-/- adults laid 40% more eggs than their wild-type siblings. The sst1.1-/- and sst1.2-/- mutants had divergent metabolic phenotypes: the former had 25% more pancreatic alpha-cells, were hyperglycaemic and glucose intolerant, and had increased adipocyte mass; the latter had 25% more pancreatic beta-cells, improved glucose clearance and reduced adipocyte mass.ConclusionsWe conclude that somatostatin signalling regulates energy metabolism and fecundity through anti-proliferative and modulatory actions on primordial germ cells, pancreatic insulin and glucagon cells and the hypothalamus. The ancient origin of the somatostatin system suggests it could act as a switch linking metabolism and reproduction across vertebrates. The results raise the possibility of applications in human and animal fertility.eng
dc.identifier.doi10.1186/s12915-024-01961-7
dc.identifier.issn1741-7007
dc.identifier.urihttp://hdl.handle.net/10400.1/25961
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBioMed Central
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationSomatostatin regulation of fecundity and potential application to sturgeon roe production
dc.relation.ispartofBMC Biology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTrade-offFecundity
dc.subjectMetabolism
dc.subjectDiabetes
dc.subjectZebrafish
dc.subjectPancreas
dc.subjectOvary
dc.titleSomatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafisheng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleSomatostatin regulation of fecundity and potential application to sturgeon roe production
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.1/25960
oaire.citation.issue1
oaire.citation.startPage163
oaire.citation.titleBMC Biology
oaire.citation.volume22
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameChen
person.familyNameMartins
person.familyNameCanario
person.givenNameJie
person.givenNameRute Sofia Tavares
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id9210-A59A-9203
person.identifier.ciencia-idA418-0899-1BD9
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0001-5804-2981
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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