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Role of MOB4 in cell proliferation and neurogenesis

2023-12-06Journal article Open Access
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dc.contributor.authorBaião Santos, Inês
dc.contributor.authorGARRIDO-MARAVER, JUAN
dc.contributor.authorGonçalves, Carolina
dc.contributor.authorOliveira, Bruna
dc.contributor.authorTavares, Alvaro A.
dc.date.accessioned2024-01-05T14:24:01Z
dc.date.available2024-01-05T14:24:01Z
dc.date.issued2023-12-06
dc.date.updated2023-12-22T13:45:09Z
dc.description.abstractSignaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and is simultaneously involved in synapse formation and neural development. In addition, the gene is often overexpressed in a large diversity of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and the development of tissues and individuals.pt_PT
dc.description.sponsorshipGrant number ALG-01-0145-FEDER-030014pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBioChem 3 (4): 182-196 (2023)pt_PT
dc.identifier.doi10.3390/biochem3040013pt_PT
dc.identifier.eissn2673-6411
dc.identifier.urihttp://hdl.handle.net/10400.1/20277
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThe control of cell proliferation in high eukariotes - cellular and molecular functions of Mob2 in cell division
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCell proliferationpt_PT
dc.subjectNeurogenesispt_PT
dc.subjectSpermatogenesispt_PT
dc.subjectHippo pathwaypt_PT
dc.subjectSTRIPAKpt_PT
dc.subjectMob4pt_PT
dc.titleRole of MOB4 in cell proliferation and neurogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe control of cell proliferation in high eukariotes - cellular and molecular functions of Mob2 in cell division
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FBIA-CEL%2F30014%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F141734%2F2018/PT
oaire.citation.endPage196pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage182pt_PT
oaire.citation.titleBioChempt_PT
oaire.citation.volume3pt_PT
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
oaire.fundingStreamOE
person.familyNameBaião Santos
person.familyNameGARRIDO-MARAVER
person.familyNameTavares
person.givenNameInês
person.givenNameJUAN
person.givenNameAlvaro
person.identifier3083838
person.identifier.ciencia-idA214-19E1-B91D
person.identifier.ciencia-id2F19-FB37-2D0C
person.identifier.ciencia-idAD12-B7F1-969B
person.identifier.orcid0000-0002-5973-9980
person.identifier.orcid0000-0003-4534-4109
person.identifier.orcid0000-0002-7137-0944
person.identifier.ridS-3846-2016
person.identifier.scopus-author-id26026590800
person.identifier.scopus-author-id19036533500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1bed0c85-bccd-4a3b-b1a5-6103a9467c15
relation.isAuthorOfPublicationb44cba91-e2b1-4439-ba25-6ec1d68a059c
relation.isAuthorOfPublication.latestForDiscoveryb44cba91-e2b1-4439-ba25-6ec1d68a059c
relation.isProjectOfPublication72b0896a-10ac-4e72-828d-a347331da23f
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